The HMB-FA randomized trial: Not Sure If….
Wow. It finally happened.
On first glance, I haven’t seen data this promising about a supplement since…ever. HMB (beta-hydroxy-beta-metahybutyrate) has been so _unpromising_ since its emergence back in the late 1990’s/early 2000’s, that I had basically stopped reading about it. And then Andrew Vigotsky mentioned me on Twitter and…well, consider me initially genuinely excited. Which is rare. Like, the next thing that might happen is a rain of frogs. But then I dug a little bit. Read More...
Beta-alanine redux: Same question, still no answer. But they still recommend you take it.
It’s been three years since I’ve written about beta-alanine. I do monitor the literature from time to time to see what’s new in the BA research world. But really, there isn’t anything new. There still is no definitive answer that BA does anything meaningful. The latest BA study not only failed to find anything meaningful, but also failed to plan to find anything meaningful, allowing the gods of statistical probability to decide if the fruits of their labour would be met with reward.
Kern BD, Robinson TL. Effects of beta-alanine supplementation on performance and body composition in collegiate wrestlers and football players. Journal of Strength and Conditioning Research, 25(7):1804-1815, 2011. Read More...
Belief shouldn’t be part of why something works (unless it’s curing cancer)
But supplements, diets and workout programs shouldn’t be things that require your belief. Read More...
Fear of loss: How the fitness claims get you
All through my undergraduate “career”, I worked in labs. Just as there are gym rats, I was a lab rat. Great experience for me. Okay pay for a student. But when I finished my undergrad, I already knew I was going to start my Masters in the fall. And at the time, I also felt that I had never really earned an honest dollar. I had never set foot outside the Ivory Tower and so I wanted to experience what a “joe job” might be like. My first choice was to be a waiter–pretty social, they seem to have a lot of fun for the most part, and the pay was probably better than my lab stipends. But in Toronto, getting a job as a waiter is tough competition. In the end, I lucked out, but there was a period of a month or so where I hadn’t found that job.
So what’s a 23 year old, freshly graduated biology major to do? Hit the want ads, of course. What happened next is a story unto itself, but the crux of the story is that I ended up doing a short stint as a door-to-door salesman with a franchise of one of the largest direct sales companies in the world. Read More...
Feel the PUMP! Um..that’s it.
Snarkiness aside, I’ve been wanting to discuss nitric oxide or NO supplements (as well as pre-workout drinks) for a long time; but oddly enough, the literature was incredibly sparse on the topic in terms of studies involving humans and outcomes training individuals would be interested in. NO-type ingredients seem to be in everything, to the point where you don’t have to _decide_ to take an NO-related ingredient, you probably just are, particularly if you’re taking anything that is designed as a pre-workout supplement. In fact, it’s amazing that they can stuff more than 30 ingredients into a single pre-workout drink such that it will still fit into a couple of scoops. Read More...
How much would you pay for 2 more reps at the end of your workout?
The concept of progressive overload is a cornerstone to any weight-training program. Lifting more weight, or lifting the same weight for more reps is the goal that is theorized to produce muscle growth, or better performance (however you decide to measure that).
Citrulline malate has been an ingredient in a multitude of sport supplements. It is theorized to work through 3 proposed mechanisms: 1) malate is proposed to accelerate ammonium clearance and citrulline is proposed to facilitate lactate metabolism (these effects however, were noted in microbial models, i.e. germs in a dish); 2) citrulline malate has been noted to protect against acidosis which is proposed to counter fatigue; 3) Citrulline malate is proposed to increase nitric oxide production, which has been shown to have many potentially physiologically beneficial effects (though none of these effects may affect the stuff you’re concerned about like muscle growth, fat loss, or any performance benefit). Read More...
Beta-alanine revisited: Failing to plan, or planning to fail?
In the past 2.5 years, a few more studies on beta-alanine have emerged. As I’ve written before, my goal isn’t to become the anti-beta-alanine blogger, but I do feel that watching this supplement develop from its relative inception to its current state does provide an interesting prototype for how similar products develop a strong following despite the limitations on the research available to support (or not support) its use. Read More...
You don’t always get what you want, even if you get what you need
One of the newer supplements on the market are the aromatase inhibitors. They purport to increase free testosterone levels by inhibiting the enzyme that is responsible for converting androstenedione to estrone as well as converting testosterone to estradiol. By preventing the breakdown of testosterone precursors and the breakdown of testosterone itself, the concentration of testosterone should theoretically increase. Read More...
Beta-alanine: The Harris Study (this is what grad students are actually used for)
I was going to write a review of the Harris study on beta-alanine, but after reading it in detail, I realized it wasn’t a randomized controlled trial at all, but rather a physiological study, with biochemical outcomes, but no “functional” ones. And despite the fact that one of their experiments was a “quasi” randomized controlled trial, I haven’t got a lot to say about it because this was not a study to look at the effectiveness of BA, but rather to profile its effects. On the up side, there was a rather nice recipe for chicken broth–which is where they got their beta-alanine for one of the experimental groups: Read More...
Another beta-alanine study. Don’t buy the hype.
Some day, I’m going to preface a review with a sentence like, “Today’s study was really well done. I was impressed by the comprehensiveness of the reporting, the concise data analysis and the practical relevance of the trial.” Read More...